(Ars Technica) Facebook computers compromised by zero-day Java exploit

As this case shows, traditional software security methods are ineffective against new threats.
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Antivirus software was unable to detect the malware because "it was novel," said Sullivan. "The fact that the machines were patched didn't slow down the attackers."

http://arstechnica.com/security/2013/02/facebook-computers-compromised-by-zero-day-java-exploit/